About to be married, Robert Twigger decides on his last great adventure as a bachelor. Surfing the net, he discovers the Roosevelt Prize worth $50,000 for the capture of a live 30 foot python. Armed only with a tin of High Toast Snuff (deadly if sniffed by a snake), Twigger sets off into the remote jungles of Indonesia in search of his prey.



Along the way, he investigates the legendarily beautiful women of Sulawesi, treads in Nabokov's footsteps, looks for giant snakes beneath the sewers of Kuala Lumpur, and spends time with a variety of snake catchers and cults. After being caught up in anti-Chinese riots and surviving on greasy civet cat in the jungle, Twigger finally comes face to face with the big one; but the final capture is not quite what he had in mind.