Neglected tropical diseases (NTDs) elimination and control efforts are recognized as one of the most cost-effective interventions in global health today. In addition to preventing and reducing disease and disability, NTD elimination and control efforts help maximize the impact of cross-sectoral programmes. These programmes include education, water and sanitation, food safety, nutrition and climate change adaptation. It is critical to work across sectors and leverage integrated approaches at a time when donors, policy-makers and programme managers must improve efficiency to achieve scale and impact with limited resources. This publication underscores the importance of tackling NTDs in order to help alleviate suffering, reduce poverty and ensure the continued social and economic growth of the region. As a joint production by the World Health Organization Regional Offices for South-East Asia and the Western Pacific, the Asian Development Bank and the Global Network for Neglected Tropical Diseases at the Sabin Vaccine Institute, this publication highlights the need for greater crosssectoral partnership and additional investments.