Held at the Karolinska Instituet, in Stockholm, Sweden, a recent Nobel Minisymposium, "Molecular Oncology - From Bench to Bedside," marked a very special event-the celebration of George and Eva Klein's combined 160th birthdays. To honor this occasion, Volume 97 of Advances in Cancer Research brings together a collection of contributions by their former students, colleagues, and collaborators from the past fifty years-dedicated to George and Eva Klein. Over a decade ago, the editors of ACR initiated a subdivision of the series called "Foundations in Cancer Research" to distinguish chapters that reflect extraordinary and historical developments in cancer research- this volume of tributes honoring the Kleins' bodies of work presented at the minisymposium are especially appropriate for the series and should serve as an important resource for future generations.