The annotations cover the full range of information referenced in Ulysses: a vast array of literary allusions, such as Shakespeare, Aristotle, Dante, Aquinas, slang from various eras and areas, foreign language words and phrases, Hiberno-English expressions, Catholic ritual and theology, Irish histories, Theosophy, Freemasonry, cricket, astronomy, fashion, boxing, heraldry, the symbolism of tattoos, horse racing, advertising slogans, nursery rhymes, superstitions, music-hall songs, references to Dublin topography precise enough for a city directory, and much more besides.

The annotations reflect the latest scholarship and have been thoroughly reviewed by an international team of experts. They are designed to be accessible to first-time readers and college students and will also serve as a resource for Joycean specialists. The volume includes contemporaneous maps of Dublin to illustrate the cityscape's relevance to Joyce's novel. Unlike previous volumes of annotations, almost every note includes documentation about sources.