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Cell Adhesion and Migration in Skin Disease

Cell Adhesion and Migration in Skin Disease

by John McGrath and Jonathan Barker
Hardback
Publication Date: 07/03/2001

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The past few years have seen considerable advances in our understanding of the molecular basis underlying cutaneous cell adhesion mechanisms. Co-authored by a number of leading experts in the field Cell Adhesion and Migration in Skin Disease provides a comprehensive overview of the critical role played by cell adhesion in determining the structure and function of both healthy and diseased human skin. The book is divided into three main sections, with each one addressing a principal function of adhesion molecules.The first part focuses on the epidermis, which as the skin's outermost layer, acts as the human body's primary barrier of defence. Roles played by cytoskeletal intermediate filaments and junctional complexes in cutaneous cell adhesion are emphasised with descriptions of blistering skin diseases that can arise if these molecules malfunction.The second part describes the macromolecular interactions responsible for the anchorage of cells to the underlying extracellular basement membrane.
The experimental approaches detailed in the text not only reveal how the molecular components of the dermal-epidermal junction have been elucidated, but also highlight how mutations in the genes which encode these molecules are responsible for many heritable skin diseases. Leukocytes continually infiltrate the skin and patrol it for potentially harmful pathogens. Control of leukocyte adhesion to resident cells within the skin and to the extracellular matrix plays a key role in controlling these processes. These mechanisms constitute the primary focus of the final section. The pivotal role of leukocytes is examined in conjunction with the chronic inflammatory diseases which arise when components of the skin's finely tuned defence strategy go awry and the potential for these anomalies to be pinpointed as important immunotherapeutic targets for skin diseases.
ISBN:
9789058230676
9789058230676
Category:
Dermatology
Format:
Hardback
Publication Date:
07-03-2001
Publisher:
Taylor & Francis Ltd
Country of origin:
United Kingdom
Pages:
284
Dimensions (mm):
246x174x23mm
Weight:
0.84kg
John McGrath

John McGrath was born in Birkenhead, Cheshire, in 1935. After national service and Oxford University, he wrote and directed for theatre and television, as well as writing for cinema. Early work included Z-Cars for BBC-TV (1962), Events While Guarding the Bofors Gun (1966) and the screenplay for Billion Dollar Brain (1976). In 1971, together with Elizabeth MacLennan, he co-founded the 7:84 Theatre Company, which divided into Scottish and English companies in 1973 with McGrath remaining as Artistic Director of both. During his career McGrath wrote over 60 plays, including Fish in the Sea (1972), The Cheviot, the Stag and the Black, Black Oil (1973), Blood Red Roses (1980), Border Warfare (1989), Watching for Dolphins (1992) and, most recently, HyperLynx (2001). He was twice Visiting Fellow in Theatre at Cambridge University. His previous books include A Good Night Out (1981), The Bone Won't Break (1990) and Six Pack: Plays for Scotland (1996).


McGrath founded Freeway Films in 1982, for which he produced, amongst others, The Dressmaker (1985), Carrington (1995), Ma Vie en Rose (1997) and Aberdeen (2002). He also founded Moonstone International Screen Labs to support and promote independent European filmmaking. He received Lifetime Achievement Awards from both BAFTA (in 1993) and the Writers' Guild of Great Britain (in 1997), as well as Honorary Doctorates from the University of Stirling and the University of London. He died in 2002.

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