Mitochondrial energy shortfall has long been considered an important agent across a range of clinical pathologies - from inherited disorders that affect energy metabolism to intoxications, cardiometabolic and neurodegenerative diseases. Bioenergetics - the study of the transformation of energy in living organisms-- stands as a growing, innovative discipline tackling functional aspects of energy metabolism in biological processes and disease.

Clinical Bioenergetics: From Pathophysiology to Clinical Translation provides an in-depth view of recent developments in understanding the etiology and pathophysiology of inherited and acquired energy-delated disorders. Across 40 chapters, world leaders in bioenergetics and mitochondrial medicine discuss novel methodologies designed to identify deficiencies in cellular bioenergetics, as well as the safety and efficacy of emerging management strategies to address poor cellular bioenergetics. Early foundational chapters offer a strong basis in foundational aspects of bioenergetics and disease, including the omics landscape of impaired mitochondrial bioenergetics; and hormones, tissue bioenergetics and metabolism in humans. Disease-specific case studies, modes of analysis in clinical bioenergetics, and therapeutic opportunities for impaired bioenergetics, addressing both known treatment pathways and future directions for research, are discussed in-depth. Diseases and Disorders examined include brain injury, chronic fatigue syndrome, psychiatric disorders, pulmonary fibrosis, neurodegenerative disorders, heart failure, chronic kidney disease, obesity, and insulin resistance, among others.