This is a significant contribution within and across High Energy Physics and Algebraic Combinatorics. It is at the forefront of the recent paradigm shift according to which physical observables emerge from geometry and combinatorics. The book looks at the amplituhedron, which encodes the scattering amplitudes of N=4 Yang-Mills theory, a cousin of the theory of strong interactions of quarks and gluons. Amplituhedra are generalizations of polytopes inside the Grassmannian, and they build on the theory of total positivity and oriented matroids. This book unveils many new combinatorial structures of the amplituhedron and introduces a new important related object, the momentum amplituhedron. Moreover, the work pioneers the connection between amplituhedra, cluster algebras and tropical geometry.