This Computer Algebra Handbook gives a comprehensive snapshot of this field at the intersection of mathematics and computer science with applications in physics, engineering and education. It contains both theory, systems and practice of the discipline of symbolic computation and computer algebra. With the wide angle of a "lense" of about 200 contributors it shows the state of computer algebra research and applications in the last decade of the twentieth century. Aside from discussing the foundations of computer algebra, the handbook describes 67 software systems and packages that perform tasks in symbolic computation. In addition, the handbook offers 100 pages on applications in physics, mathematics, computer science, engineering chemistry and education. The book is accompanied by a CD-ROM, containing demo versions for most of the computer algebra systems treated in the book, as well as links to further information on some of these. This book will be very useful as a reference to graduate students and researchers in symbolic computation and computer algebra.