A wide variety of topics of bio-informatics, including both medical and bio-medical informatics are addressed by MIE. The main theme in this publication is the development of connections between bio-informatics and medical informatics. Tools and concepts from both disciplines can complement each other. Information derived at the molecular level influences patient care processes. As new bridges must be built, a panel of high-level scientists was invited to participate and to give keynote speeches, tutorials and workshop discussions. The topics include: sharing resources between bio-informatics and medical informatics; sharing knowledge, common data and tools, interactions and potentialization for the benefit of patients; image processing and feature extraction; electronic health records and information systems; and, biosignal analysis, human interface, quality assessment, patients as citizens, statistical methods, knowledge engineering, telematics, etc.