This title addresses the role of co-operation, networks and institutions in the context of regional innovation systems. It emphasizes the importance of these factors in the emergence of local innovation systems, using detailed examples of clusters which have reached different stages of maturity. The authors address the topic from an empirical, theoretical and political perspective, and highlight the local mechanisms which are involved in the development of innovation systems. They offer a comprehensive overview of different approaches in the field and present numerous case studies which stress the influence of networks and local institutions. Significantly, they also introduce several new approaches to regional innovation systems, including contributions which explicitly discuss the design and potential of policy measures to promote regional development. The policy recommendations are based on sound theorizing which, in turn, is based on extensive empirical research.