Nowadays, mankind is living in a cyber world. Modern technologies involve fast communication links between potentially billions of devices through complex networks (satellite, mobile phone, Internet, Internet of Things (IoT), etc.). The main concern posed by these entangled complex networks is their protection against passive and active attacks that could compromise public security (sabotage, espionage, cyber-terrorism) and privacy. This Special Issue "Cryptography and Its Applications in Information Security" addresses the range of problems related to the security of information in networks and multimedia communications and to bring together researchers, practitioners, and industrials interested by such questions. It consists of eight peer-reviewed papers, however easily understandable, that cover a range of subjects and applications related security of information.