Chiaki Nanami is the Ultimate Gamer, selected as one of Japan's most expert teens to attend the elite Hope's Peak High School. What could be nicer than for the semester to kick off with a class trip to the tropical resort of Jabberwock Island? And what could be more horrific to then be told by the principal that now they're all trapped there...and the only way they can ever leave is to play a murder game!

In Vol. 3, with a new island, comes a new motive! More villainous than ever, Monokuma unleashes biological warfare in the battle for survival: the personality-altering Despair Disease that manifests itself in each infected victim with unpredictable symptoms--lies, delusions, cowardice. As it spreads through the remaining students, the healthy must find ways to treat the sick...even as they guard against something even worse happening to any of them--murder.

Can they find a cure before someone finds a body?