A crucial part of making a psychiatric diagnosis is to consider among the myriad conditions in DSM-5-TR® those diagnoses that could possibly account for the presenting symptoms. After determining this list of condidates, the next step of collecting additional clinical information-from personal history, other informants, treatment records, mental status examination, and laboratory investigations-allows a winnowing of the differential diagnosis options to the most likely contender, which becomes the initial diagnosis leading to an initial treatment plan. DSM-5-TR Handbook of Diffrential Diagnosis helps clinicians and students learning the process of psychiatric diagnosis to improve their skill in formulating a comprehensive differential diagnosis by providing a variety of approaches to consider symptomatic presentations. These include a six-step diagnostic frame work, 30 decision trees to consider the differential diagnosis of key symptoms, and 67 differential diagnosis tables for use once a tentative diagnosis has been made. Written by the DSM-5-TR Editor, an expert on psychiatric diagnosis and assessment, this handbook is fully updated to reflect developments in DSM-5-TR abd includes two new decision trees (for dissociative symptoms and repetitive pathological behaviors). The handbook also includes the DSM-5-TR Classification to facilitate coding and to povide an overview of all of the DSM-5-TR diagnoses that must be considered in formulating a differential diagnosis. Alphabetical indexes of the decision trees and differential diagnosis tables will help readers readily locate desired material. Clinicians and students learning psychiatric diagnosis faced with this most crucial task will find this handbook of enormous benefit.