Chapter 1_ Protein purification, estimation, storage and their effect on structure, function and dynamics.- Chapter 2_Molecular motor: Subdomain dynamics and mechanochemistry.- Chapter 3_Computational insights into the role of SNPs/mutations in enzyme inhibition: progress and challenges.-Chapter 4_Use of group specific reagents in active site functional group elucidation.- Chapter 5_Understanding the potential role of structurally distant amino acids in modulating the structure and activity of proteins.- Chapter 6_Role of human genetic variations in the modulation of enzyme efficacy and activity of metabolic and xenobiotic metabolizing enzymes.- Chatper 7_Computational protein structure modeling: The gateway for drug design.- Chapter 8_Molecular dynamics simulation study of protein and protein-ligand complexes.- Chapter 9_Protein-protein interactions modeling: from wet to dry lab approaches