8 1/2 X 10 15/16 in ar molecular species in situ. This technique has allowed the identificat ion of many more cell types than could be visualized by classical histol ogy, particularly in the immune system and among the scattered hormone-s ecreting cells of the endocrine system, and has the potential to improve diagnosis, prognosis and therapeutic options of cancer. This book discu sses all aspects of immunohistochemistry and in situ hybridization techn ologies and the important role they play in reaching a cancer diagnosis. It provides step-by-step instructions on the methods of additional mole cular technologies such as DNA microarrays, and microdissection, along w ith the benefits and limitations of each method. The topics of region-sp ecific gene expression, its role in cancer development and the technique s that assist in the understanding of the molecular basis of disease are releva