The geography of innovation is changing. First, it is increasingly understood that innovative firms and organizations exhibit a wide variety of strategies, each being differently attuned to diverse geographic contexts. Second, and concomitantly, the idea that cities, clusters and physical proximity are essential for innovation is evolving under the weight of new theorizing and empirical evidence. In this Handbook we gather 28 chapters by scholars with widely differing views on what constitutes the geography of innovation. The aim of the Handbook is to break with the many ideas and concepts that emerged during the course of the 1980s and 1990s, and to fully take into account the new reality of the internet, mobile communication technologies, personal mobility and globalization. This does not entail the rejection of well-established and supported ideas, but instead allows for a series of new ideas and authors to enter the arena and provoke debate.