The Twelfth Annual Midwest Conference on Endocrinology and Metabolism continued the tradition of selecting a topic of inter- est to a wide variety of scientists with interests in biology. The conference an "Hormones and Energy Metabolism" was dedicated appro- priately to Dr. Samuel A. Brody, a leader in research in this field as described by Professor Johnson in this volume. A particular feature of these conferences has been the large proportion of time devoted to discussion of each paper and the pub- lished proceedings have included edited transcripts of these dis- cussions. Unfortunately, due to malfunction of the recording sys- tem, major portians of the discussions were lost and, despite much effort, insufficient was salvageable tobe meaningful and helpful. Consequently, the editors decided to omit completely the discus- sions except for a communication provided by Dr. Woodside. We again express our appreciation to the staff of Conferences and Short Courses, University of r issouri-Columbia Extension Divi- sion and especially to Dr. John Swanson who helped organize the multitude of administrative details; to lrs. Linda Bennett, CPS, for her continuing excellent efforts in typing the manuscripts for publication; and particularly to the sponsors, without whom there would have been no conference. Ralph R. Anderson f-1urray Heimberg David r . Klachko vii CONTENTS Dedication: Dr. Samuel A. Brody xi Brody Memorial Lecture: Same Aspects of Energy Coupling by Mitochondria .......... .