This innovative book offers a critical perspective on the state of the current global economy, making sense of knowledge-related issues by critically assessing existing institutional choices, as well as pointing to new ways forward. The pioneering chapters reposition knowledge in a number of economic debates including regional development, property rights, social enterprises, corporate governance, the management of universities, and the role of creative activities. They explore the possibility of an institutional dynamism that impacts not only on the characteristics of localities and their place in a hierarchical and ordered system of relationships, but on the nature of the system itself. Conclusions point at the individual and collective dimensions of the knowledge discovery process, suggesting a renewed approach to the assessment of economic choices. This insightful book offers an original perspective on knowledge-related issues and constitutes a valuable read for academics and postgraduate students in international business and economic competitiveness, as well practitioners and policymakers who are interested in alternative analyses and methods for economic development.