The 730 revised full papers presented were carefully reviewed and selected from a total of 2250 submissions. The papers are organized in the following topical sections:

Part I: Machine learning with limited supervision and machine learning - transfer learning;

Part II: Machine learning - learning strategies; machine learning - explainability, bias, and uncertainty;

Part III: Machine learning - explainability, bias and uncertainty; image segmentation;

Part IV: Image segmentation;

Part V: Computer-aided diagnosis;

Part VI: Computer-aided diagnosis; computational pathology;

Part VII: Clinical applications - abdomen; clinical applications - breast; clinical applications - cardiac; clinical applications - dermatology; clinical applications - fetal imaging; clinical applications - lung; clinical applications - musculoskeletal; clinical applications - oncology; clinical applications - ophthalmology; clinical applications - vascular;

Part VIII: Clinical applications - neuroimaging; microscopy;

Part IX: Image-guided intervention, surgical planning, and data science;

Part X: Image reconstruction and image registration.