Innovative and creative labour is increasingly recognised as having a key role in regional economic development. The more advanced the processes of innovation-led entrepreneurship are, the more important become highly skilled scientific, engineering, professional and university trained personnel. This has led to the existing concentration in Europe and the US of innovative labour in a limited number of locations (as elsewhere in the world) and the tendency, on both continents for further concentration at these "Islands of Innovation". Both patterns have clear consequences for the availability of skills in question. Those regions that are able to attract and retain highly skilled labour will thrive while other regions may struggle. This book analyzes these processes with a concentration on the regionalisation of innovative labour markets and the migration of such labour to these areas.