In Pale Rider, Laura Spinney recounts the story of an overlooked pandemic, tracing it from Alaska to Brazil, from Persia to Spain, and from South Africa to Odessa. Telling the story from the point of view of those who lived through it, she shows how the pandemic was shaped by the interaction of a virus and the humans it encountered; and how this devastating natural experiment put both the ingenuity and the vulnerability of humans to the test.

Drawing on the latest research in history, virology, epidemiology, psychology, and economics, Laura Spinney narrates a catastrophe that changed humanity for decades to come, and continues to make itself felt today. In the process she demonstrates that the Spanish flu was as significant - if not more so - as two world wars in shaping the modern world; in disrupting, and often permanently altering, global politics, race relations, family structures, and thinking across medicine, religion and the arts.