This book includes high-quality papers presented at International Conference on Scientific and Natural Computing (SNC 2021), organized by Department of Applied Mathematics, Gautam Buddha University, Greater Noida in collaboration with IIT Roorkee and Technical University of Ostrava (VSB-TU) and technically sponsored by Soft Computing Research Society of India, held online during 5 - 6 February 2021. The topics include self-organizing migrating algorithm, genetic algorithms, swarm intelligence based techniques, evolutionary computing, fuzzy computing, probabilistic computing, genetic programming, particle swarm optimization, neuro computing, hybrid methods, deep learning, including convolutional neural networks, generative adversarial networks and auto-encoders, bio-inspired systems, data mining, data visualization, intelligent agents, engineering design optimization, multi-objective optimization, fault diagnosis, decision support, robotics, signal or image processing, system identification and modelling, systems integration, time series prediction, virtual reality, vision or pattern recognition, intelligent information retrieval, motion control and power electronics, Internet of Everything (IoE), control systems, and supply chain management.