W.V. Quine, a champion of philosophical naturalism and pioneer of mathematical logic, was one of the most important philosophers of the 20th century. Contemporary thought in ontology, epistemology, and the philosophy of logic and language owes much to his influence, yet recent work in these areas has become increasingly dismissive of his views. This is often because of mistaken or overly simplified conceptions of his philosophy which overlook the development of his views over time, in particular the growing importance of a kind of structuralism to his system as it evolved. This volume provides a fuller, richer picture of Quine's views and their development. With contributions from leading philosophers in a range of subfields including philosophical logic, philosophy of language, history of philosophy, mathematics, philosophy of time, and set theory, it is the first to investigate Quine's views on structure and how it permeates and shapes his attitude to a range of philosophical questions.