Successes and Challenges of NK Immunotherapy: Increasing Anti-tumor Efficacy describes the very novel and unique therapeutic applications of NK cells to fight cancers and, primarily, eliminate both the bulk and the subset of cancer stem cells responsible for metastasis, relapse and recurrences. It provides up to date information on the development, engineering, mechanisms of action, response to various preclinical models, and current applications in various clinical trials. 

The book covers the state of the art on the development of highly engineered cytotoxic NK cells, their mechanisms of action, preclinical and clinical applications, the development and application of CAR-NK cells, as well as new NK-drug conjugates in order to potentiate their anti-tumor activities. In addition, the book emphasizes that, unlike other immunotherapeutic approaches, the activated NK cells can also target and kill the highly resistant cancer stem cells that are responsible for the relapses and recurrences by all other therapeutic treatments. 

Written by the leading experts on NK immunotherapy worldwide, this is a valuable resource for researchers, clinicians, and members of biomedical field who are interested in understanding novel and efficient therapies to fight cancers.