These proceedings represent the scientific outcome of the 13th EFITA International Conference held on May 2021, which was organized by the European Federation for Information Technology in Agriculture, Food, and the Environment (EFITA). EFITA, for more than 20 years, has presented and disseminated cutting-edge research on advances in ICT systems in agriculture. The content of these proceedings brings together the efforts of engineers, scientists, technicians, academics and the industry through the exchange of knowledge and ideas, the presentation of innovations, and by discussing the state of the art and future use of ICT in the agri-food and bio-resources production sectors, under the theme of "Digital Agriculture".