This volume gives a comprehensive and integrated overview of current knowledge about the local interstellar medium (LISM) surrounding our heliosphere (HS). It is the result of the first workshop at ISSI, where both space physicists and astronomers presented and discussed their views on the density, velocity, temperature, composition, and morphology of the LISM and how it interacts with the HS. Thevolume is a combination of data obtained by remote UV, EUV, and X-ray observations outside the HS with in situ observations of interstellar atoms, ions, and dust inside the HS. It thus demonstrates a new synergy between these two communities. The book is intended to provide active researchers in space physics and in astronomy with an up-to-date status report of its topic, and also to furnish the advanced graduate student with introductory material into the field.