This textbook discusses the development and analysis of polygeneration systems to generate electricity, fresh water, hot air, cold air, and hot water from a source of energy. Topics covered in this book are desalination with no pressure or vacuum components; combined use of refrigerator and heat pump with a vapor compression refrigeration (VCR) cycle; binary fluid polygeneration; compact units; and flexible operation. It covers four polygeneration configurations, viz. binary fluid polygeneration with single-stage HDH, binary fluid polygeneration with double-stage HDH, heat pump polygeneration with single-stage HDH, and heat pump polygeneration with double-stage polygeneration. End-of-chapter problems and solved examples aid in self learning of the students. The textbook is useful for graduate and advanced graduate students studying courses such as polygeneration, sustainable energy, power generation, and alike. This book is also a useful supplementary text for researchers in fluid dynamics, thermal engineering, and allied fields.