I. Clinical Topics.- The Clinical Profile of Sepsis and the Adult Respiratory Distress Syndrome.- The Participation of the Complement System in Atherosclerotic Vascular Disease.- The Spectrum of Atherosclerosis in the Human.- Cerebral Endothelial Injury in Stroke, Brain Trauma and Hypertension.- II. General Concepts in Endothelial Cell Pathophysiology.- Free-Radical Mediated Actions on Endothelial Cells of the Intact Lung.- Regulation of Vascular Function by Vascular Permeability Factor.- III. Chemical Mediators of Endothelial Cell Injury.- Endothelial Cells as Targets for and Producers of Cytokines.- Roles of Vascular Cells in Inflammation and Immunopathology.- The Biochemistry, Cell and Molecular Biology of Type 1 Plasminogen Activator Inhibitor.- IV. Endothelial Cell Interaction with Blood Components.- Purine Regulation of Endothelial Cells: Relevance to Pathophysiology.- Autoantibodies to Endothelial Cells.- Leukocyte-Endothelial Cell Interactions.- V. Vascular Responses to Endothelial Cell Injury.- Endothelial Function in Human Coronary Bypass Grafts.- Altered Renovascular Endothelial Functions During Nephrotoxicity.- Cerebral Endothelial Function: Physiology and Pathophysiology.- Mechanisms of Altered Reactivity in the Cerebral Microcirculation.- VI. Mechanisms of Endothelial Cell Dysfunction.- The Role of Apolipoprotein E and Apolipoprotein B in Atherosclerosis.- Endothelial Cell-Matrix Interactions in Health and Disease.- Biosynthesis and Assembly of von Willebrand Factor by Vascular Endothelial Cells: Relevance to Pathophysiology.- VII. Markers of Endothelial Cell Injury and Repair.- Monitoring of Endothelial Plasmalemmal Ectoenzyme Function as an Index of Endothelial Injury and Repair.- Pathophysiological Significance of Endothelial Cell Integrins.- VIII. Epilogue.- Vascular Endothelium: Physiological Basis of Clinical Problems.- IX. Abstracts of Oral and Poster Presentations.- X. List of Participants.- XI. Index.