A Glance at the “Current Emerging Therapies” in Chronic Spontaneous Urticaria.

Chronic urticaria (CU) is characterized by: Wheals, Angioedema, or both for longer than 6 weeks.

CU can be further divided into:

1.Chronic spontaneous urticaria (CSU) and

2. Chronic inducible urticaria (CIndU).

Chronic spontaneous urticaria (CSU) is characterized by typically short-lived and fleeting wheals, angioedema or both, which occur spontaneously and persist for longer than 6 weeks.

This term is applied to the most common subtype of chronic urticaria.

It is attempted to describe the underlying pathophysiology for CSU, comprehensively.

Although a variety of treatments exist, many patients do not tolerate or benefit from the existing therapies and even require more effective treatments.

Omalizumab is currently the only licensed biologic for antihistamine-refractory CSU, and novel drugs are under development.

Thus it is strived in this E-Booklet to review its current status regarding pathogenesis and approach to treatment as well as therapeutic agents that are under development for the treatment of CSU along with few relevant ILLUSTRATIONS for better understanding.

…Dr. H. K. Saboowala.

M.B.(Bom) .M.R.S.H.(London)