The Asian Development Bank hosted the Asia-Pacific Rural Development and Food Security Forum 2022 to prompt governments to provide leadership to rethink the future of agriculture amid complex and evolving challenges; explore new research, innovations, and technologies to build nature-positive food systems; and forge partnerships and collaboration to mobilize financing for innovation, research, and business for food and nutrition security. This publication provides the forum’s key highlights and takeaways on sustainable, resilient, and inclusive food systems, financing for sustainable agriculture and natural capital, nutrition security, and the rural–urban divide, and offers recommendations for moving forward.