This issue of Neurosurgery Clinics, edited by Drs. Shahid Nimjee and Russell Lonser, will cover Coagulation and Hematology in Neurological Surgery. Topics include Biology of coagulation and coagulopathy; Evaluation of the coagulation in the neurosurgery patient; Genetics of hyper- and hypo-coagulable states; Anticoagulants: pharmacokinetics, mechanisms of action and indications; Use of antiplatelet agents in the neurosurgical patient; Common conditions requiring long-term anti-coagulation in the neurosurgical patient; Reversal of systemic and antiplatelet anticoagulants; Intraoperative blood and factor replacement neurosurgery; Management of Intraoperative coagulopathy; Deep vein thrombosis prophylaxis in the neurosurgical patient; Postoperative anticoagulation after neurological surgery; Management of venous sinus thrombosis; Management of acute ischemic thrombosis; and Management of intracranial hemorrhage the anticoagulated patient.