This book elucidates how cyberGIS (that is, new-generation geographic information science and systems (GIS) based on advanced computing and cyberinfrastructure) transforms computation- and data-intensive geospatial discovery and innovation. It comprehensively addresses opportunities and challenges, roadmaps for research and development, and major progress, trends, and impacts of cyberGIS in the era of big data. The book serves as an authoritative source of information to fill the void of introducing this exciting and growing field. By providing a set of representative applications and science drivers of cyberGIS, this book demonstrates how cyberGIS has been advanced to enable cutting-edge scientific research and innovative geospatial application development. Such cyberGIS advances are contextualized as diverse but interrelated science and technology frontiers. The book also emphasizes several important social dimensions of cyberGIS such as for empowering deliberative civic engagement and enabling collaborative problem solving through structured participation. In sum, this book will be a great resource to students, academics, and geospatial professionals for leaning cutting-edge cyberGIS, geospatial data science, high-performance computing, and related applications and sciences.