This two-volume set, LNCS 13426 and 13427, constitutes the thoroughly refereed proceedings of the 33rd International Conference on Database and Expert Systems Applications, DEXA 2022, held in Vienna in August 2022.

The 43 full papers presented together with 20 short papers in these volumes were carefully reviewed and selected from a total of 120 submissions. The papers are organized around the following topics: Big Data Management and Analytics, Consistency, Integrity, Quality of Data, Constraint Modelling and Processing, Database Federation and Integration, Interoperability, Multi-Databases, Data and Information Semantics, Data Integration, Metadata Management, and Interoperability, Data Structures and much more.