This book constitutes the refereed proceedings of the 15th International Conference on Graph Transformation, ICGT 2022, which took place Nantes, France in July 2022.

The 10 full papers and 1 tool paper presented in this book were carefully reviewed and selected from 19 submissions. The conference focuses on describing new unpublished contributions in the theory and applications of graph transformation as well as tool presentation papers that demonstrate main new features and functionalities of graph-based tools.