This book constitutes the refereed proceedings of the 12th International Conference on High-Performance Computing Systems and Technologies in Scientific Research, Automation of Control and Production, HPCST 2022, held in Barnaul, Russia, during May 20–21, 2022.

The 23 full papers included in this book were carefully reviewed and selected from 116 submissions. They were organized in topical sections as follows: hardware for high-performance computing and signal processing; information technologies and computer simulation of physical phenomena; computing technologies in data analysis and decision making; and computing technologies in information security applications.