This book constitutes the refereed revised selected papers of the 11th Latin American Conference on High Performance Computing, CARLA 2024, held in Santiago de Chile, Chile, during September 30–October 4, 2024.

The 21 full papers included in this book were carefully reviewed and selected from 42 submissions. They were organized in topical sections as follows: High Performance Computing Track; Artificial Intelligence at HPC Scale Track; High Performance Computing Applications Track.