Histamine intolerance occurs when there is a buildup of histamine in the body. Drugs, medical conditions, the environment, nutritional deficiencies, and diet can lead to histamine intolerance.

Factors that lead to histamine intolerance cause the following:

• An increase in how much histamine a person's digestion releases.


• A decrease in the effectiveness or abundance of diamine oxidase, or DAO, the primary enzyme that breaks down ingested histamine.


• A decrease in the effectiveness or abundance of histamine-N-methyltransferase, or HNMT, an enzyme that helps break down histamine within cells.


• Histamine intolerance is fairly rare, impacting an estimated 1 percent of the population. People often mistake it for other conditions, such as food allergies and gastrointestinal diseases.

Histamine in Digestion plays a role in gastric secretion by helping to induce the production of acid in the stomach. Histamine in Sleep: The body regulates the amount of histamine in circulation and maintains a careful balance. This is most important with keeping the body awake and alert.

Like many molecules in the body, we need a Low balance of histamine. When balanced, it helps control pain, happiness, appetite, mood, memory, blood pressure, motivation, sleep/wake cycle, and much more. Sometimes, the body doesn't break down histamine properly, which results in persistent inflammation.

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