This book constitutes the refereed proceedings of the 17th International Conference on Hybrid Artificial Intelligent Systems, HAIS 2022, held in Salamanca, Spain, in September 2022.

The 43 full papers presented in this book were carefully reviewed and selected from 67 submissions. They were organized in topical sections as follows: bioinformatics; data mining and decision support systems; deep learning; evolutionary computation; HAIS applications; image and speech signal processing; and optimization techniques.