Scimat (Science Matters) is the new multidiscipline that deals with the science of humans. It aims to raise the scientific level of the humanities by encouraging interaction between humanists and natural scientists. This book Interdisciplinarity and General Education in the 21st Century derives from the fifth international scimat conference of the same title, held in Cascais, Portugal, in October 2015, at Muchaxo Hotel, one of the most ancient icons of the charming Atlantic Coast. A great diversity of themes is well portrayed in this volume which contains 12 chapters written by 12 expert humanists and scientists and it is organized in three parts, ranging from Interdisciplinarity and General Education to Other Science Matters.