This book constitutes the refereed post-conference proceedings of the Fifth IFIP International Cross-Domain Conference on Internet of Things, IFIPIoT 2022, held in Amsterdam in October 2022.

The 20 full papers presented were carefully reviewed and selected from 36 submissions. The papers are organized in the following topical sections: IoT for Smart Villages, Security and Safety, Smart Home, Development, Engineering, Machine Learning, and Applications.