Nathan Jericho and his best friend, Marcus, are professional bank robbers. Always riding into one predicament or another, the two suddenly find themselves captured by a group of four well-known bounty hunters, led by none other than the infamous Alexander Sazonov. Nathan and Marcus figure their days of freedom are numbered, accepting to the fact that the rewards for them both would soon be cashed in.

Alexander, on the other hand, had other ideas. His sister, Susan, had been captured by a renegade band of Tecumseh warriors. Knowing the reputations of both Jericho and Marcus for their excellent tracking skills and marksmanship, Alexander decides to use the skills of their prisoners to help better the odds of rescuing his sister. Nathan and Marcus find themselves in a deadly game of cat and mouse, with more 'cats' than they cared to try to elude.