In recognition of the vital need to protect legitimate facilities from the theft and misuse of dangerous pathogens and toxins, the Laboratory Biosecurity Handbook serves as a guide to the implementation of pathogen protection programs. The first sections of the book offer an historical overview of biological weapons activity, key principles of biosecurity and its integration into existing frameworks, as well as a discussion of biosecurity risk. Later sections discuss biosecurity risk assessments, describe detailed components of a biosecurity program, and offer a graded approach to biosecurity through multiple risk levels. The work also covers risk prioritization of biological assets and biosecurity training.