This book constitutes the refereed proceedings of the 14th International Conference on Large-Scale Scientific Computations, LSSC 2023, held in Sozopol, Bulgaria, during June 5–9, 2023.

The 49 full papers included in this book were carefully reviewed and selected from 61 submissions. They were organized in topical sections as follows: preconditioning and multilevel methods; fractures and mixed dimensional modeling: discretizations, solvers, and methodology; machine learning and model order reduction for large scale predictive simulations; fractional differential problems: theoretical aspects, algorithms and applications; variational analysis and optimal control; stochastic optimal control and numerical methods in economics and finance; tensor methods for big data analytics and low-rank approximations of PDEs solutions; applications of metaheuristics to large-scale problems; large-scale models: numerical methods, parallel computations and applications; HPC and HPDA: algorithms and applications.