Asia and the Pacific is the most disaster-prone region in the world and water is the primary medium through which the impacts of climate change are felt. Resilient water management is central to achieving climate adaptation, managing and better preparing for natural and public health threats, and addressing water scarcity issues. This guidance note provides specific actions and tools for scaling up and mainstreaming water resilience in the region through operations of the Asian Development Bank. The guidance note is based on six pillars: (i) demand for resilient water investments; (ii) a community approach; (iii) strengthened staff capacity; (iv) knowledge, innovation, and partnerships; (v) finance for water resilience; and (vi) digitalization.