This book constitutes the refereed proceedings of the 6th International Conference on Mobile Internet Security, MobiSec 2022, held in Jeju, South Korea, in December 15–17, 2022.

The 24 full papers included in this book were carefully reviewed and selected from 60 submissions. They were organized in topical sections as follows: 5G advanced and 6G security; AI for security; cryptography and data security; cyber security; and IoT application and blockchain security.