This book gathers the latest advances, innovations, and applications in the field of multibody and mechatronic systems. Topics addressed include the analysis and synthesis of mechanisms; modelling and simulation of multibody systems; railway and vehicle dynamics; mechatronic systems for energy harvesting; robot design and optimization; and mechatronic design. It gathers the second volume of the proceedings of the 7th International Symposium on Multibody Systems and Mechatronics (MuSMe), virtually held in Cordoba, Argentina, on October 12-15, 2021, within the framework of the FEIbIM Commission for Robotics and Mechanisms and IFToMM Technical Committees for Multibody Dynamics and for Robotics and Mechatronics.