'Non-coding RNA Transcripts in Cancer Therapy: Pre-clinical and Clinical Implications' provides a new insight towards role of non-coding RNAs molecules including microRNAs, long non-coding RNAs and circular RNAs in cancer. The reason of focusing on cancer is that this malignant disease is responsible for high death around the world and after cardiovascular diseases, it is a leading cause of death. In the current book, the basic information and knowledge about ncRNAs, their biogenesis and their biological functions are covered. It is shown that ncRNAs can regulate expression level of genes at transcriptional and post-transcriptional levels and therefore, ncRNAs are master and key players in molecular pathways. Then, the impact of regulation of molecular pathways by ncRNAs on important molecular mechanisms such as proliferation, metastasis, epithelial-to-mesenchymal transition, apoptosis and autophagy are described. All of these aspects are integrated in cancer and for treatment of this disease. In case of miRNAs, their biogenesis and biological functions in physiological conditions are described. Then, impact of miRNAs on proliferation, metastasis, therapy response (drug resistance and radio-resistance) is described. For lncRNAs and circRNAs, a same way is followed and their biogenesis and functional roles in cells are discussed. At the next step, function of lncRNAs and circRNAs in regulating proliferation, metastasis and therapy response (chemoresistance and radio-resistance) is introduced. These subjects are discussed based on pre-clinical studies and in order to make the book more comprehensive and broaden its scope, the function of exosomal ncRNAs in diagnosis and prognosis of cancer patients is described.

Contents:

• MicroRNAs (miRNAs) in Cancer Proliferation: Molecular Interactions and Possible Therapeutic Targets (Shokooh Salimimoghadam, Mahshid Deldar Abad Paskeh, Sepideh Mirzaei, Mehrdad Hashemi, Azuma Kalu and Noushin Nabavi)


• MicroRNAs (miRNAs) in Cancer Metastasis: Molecular Interactions and Possible Therapeutic Targets (Mahshid Deldar Abad Paskeh, Shokooh Salimimoghadam, Sepideh Mirzaei, Mehrdad Hashemi, Azuma Kalu and Noushin Nabavi)


• MicroRNAs (miRNAs) in Therapy Response of Human Cancers: Biological Aspects*(Mahshid Deldar Abad Paskeh, Sepideh Mirzaei, Shokooh Salimimoghadam, Mehrdad Hashemi and Amir Reza Aref)*


• Exosomal miRNAs in Cancer Progression and Diagnosis (Mehrdad Hashemi, Afshin Taheriazam, Sepideh Mirzaei, Shokooh Salimimoghadam and Amir Reza Aref)


• Long Non-Coding RNAs (lncRNAs) in Cancer Proliferation: Molecular Interactions and Possible Therapeutic Targets (Maliheh Entezari, Afshin Taheriazam, Sepideh Mirzaei, Shokooh Salimimoghadam, Azuma Kalu and Noushin Nabavi)


• Long Non-Coding RNAs (lncRNAs) in Cancer Metastasis: Molecular Interactions and Possible Therapeutic Targets (Mehrdad Hashemi, Shokooh Salimimoghadam, Afshin Taheriazam and Sepideh Mirzaei)


• Long Non-Coding RNAs (lncRNAs) in Cancer Therapy Response: Biological Aspects (Mohammad Hossein Gholami, Alireza Abbaspour, Fatemeh Tajik, Amirhossein Zabolian and Zhaowu Ma)


• Exosomal Long Non-Coding RNAs (lncRNAs) in Cancer Progression and Diagnosis (Mohammad Arad Zandieh, Nazanin Ranjbar Naeini, Romina Rajabi, Shokooh Salimimoghadam, Kiavash Hushmandi, Huiyan Eng and Alan Prem Kumar)


• Circular RNAs (circRNAs) in Cancer Proliferation: Molecular Interactions and Possible Therapeutic Targets (Sepideh Mirzaei, Maryam Majidinia, Sima Orouei, Vihan Moodi, Shokooh Salimimoghadam, Maliheh Entezari, Kiavash Hushmandi, Zhaowu Ma and Lingzhi Wang)


• Circular RNAs (circRNAs) in Cancer Metastasis: Molecular Interactions and Possible Therapeutic Targets (Rasoul Raesi, Amirhossein Zabolian, Farzaneh Hasani Sadi, Salar Javanshir, Shokooh Salimimoghadam, Young Yun Jung, Kwang Seok Ahn and Sepideh Mirzaei)


• Circular RNAs (CircRNAs) in Cancer Therapy Response: Biological Aspects (Sima Orouei, Mehrdad Hashemi, Parham Rahmanian, Mohammad Hossein Gholami, Min Hee Yang and Kwang Seok Ahn)


• Exosomal Circular RNAs (circRNAs) in Cancer Progression and Diagnosis (Rasoul Raesi, Sam Saghari, Farzaneh Bassiri, Motahhar Motahhary, Shokooh Salimimoghadam, Abdurrahman Coskun and Ali Zarrabi)

Readership: Researchers, clinicians and students in genomic medicine, epigenetics, and cancer research with an interest in developing RNA-based disease therapies.

Key Features:

• Novel outline


• Focusing on biological functions


• Demonstrating role of exosomal non-coding RNAs in cancer