This book constitutes the refereed proceedings of the 6th International Workshop on Ophthalmic Medical Image Analysis, OMIA 2019, held in conjunction with the 22nd International Conference on Medical Imaging and Computer-Assisted Intervention, MICCAI 2019, in Shenzhen, China, in October 2019.

The 22 full papers (out of 36 submissions) presented at OMIA 2019 were carefully reviewed and selected. The papers cover various topics in the field of ophthalmic image analysis.