This book constitutes the refereed proceedings of the 13th International Conference on Optimization and Applications, OPTIMA 2022, held in Petrovac, Montenegro, during September 26–30, 2022.

The 17 full papers and presented were carefully reviewed and selected from 43 submissions. They were organized into the following as follows: mathematical programming; global optimization; discrete and combinatorial optimization; optimal control; optimization and data analysis; and game theory and mathematical economics.