Practical guide for the breeding off African catfish (Clarias gariepinus) discuses in a layman language processes required to breed African catfish seeds(fingerling) including water as a basic factor in catfish breeding, important things to put in place before embarking on catfish seed breeding, seed multiplication; its definition and process as well as post-hatching management of newly hatched fry. It elaborates every technical aspect of catfish breeding; construction of ponds/tank, identification of sexually matured female and male catfishes ,hormone required for breeding taking note of the dosages based on fish weight, routine management required to nurse the hatched fry to fingerling guaranteeing 95% success in nursing. This book is good for students of colleges and universities studying aquaculture and fishery or agricultural related course, lecturers or instructors teaching fish breeding as well as individual farm owners seeking to establish catfish hatchery.